Martinaud, Christophe and Mayet, Aurélie and Bousquet, Sophie and Beaufils, Nathalie and Gabert, Jean and Raynaud, Sophie and Mozziconacci, Marie-Joelle (2011) Impact of the Normalized Copy Number of <i>BCR-ABL</i> Transcript upon Diagnosis on Prognosis in CML Patients Treated with Imatinib-Mesylate. Open Journal of Blood Diseases, 01 (02). pp. 12-14. ISSN 2164-3180
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Abstract
Quantification of the BCR-ABL transcript is recommended to follow-up CML patients treated by imatinib mesylate (IM). Results are expressed as a normalized copy number (NCN) of BCR-ABL. We studied a cohort of 98 CML patients under IM as a first treatment and monitored by RQ-PCR after 12, 18 and 24 months according to the European LeukemiaNet recommendations. Our results support the hypothesis of an independent correlation between BCR-ABL NCN at diagnosis and major molecular response at 18 and 24 months in an inverse relationship. We also highlighted the possibility to use the NCN at diagnosis as a warning at diagnosis, and may be useful to identify patients who could benefit of a more rigorous follow-up.
Item Type: | Article |
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Subjects: | Open Library Press > Medical Science |
Depositing User: | Unnamed user with email support@openlibrarypress.com |
Date Deposited: | 11 Apr 2023 05:59 |
Last Modified: | 05 Sep 2024 11:02 |
URI: | http://info.euro-archives.com/id/eprint/1017 |