Marganakop, Sheetal B. and Kamble, Ravindra R. and Meti, Gangadhar Y. and Kumbar, Mahadev N. (2015) Electronic Effect of Substituents Present on Carbonyl Compounds: Analysis of Product Formation in One-Pot Synthesis of 1, 3, 4-thiadiazole Ring. American Chemical Science Journal, 8 (1). pp. 1-7. ISSN 22490205
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Abstract
Functionalized N-(4-acetyl-5-substituted-4, 5-dihydro-[1, 3, 4]-thiadiazol-2-yl)-acetamides (2a-m) were synthesized by three-fold condensation of carbonyl compound, thiosemicarbazide and acetic anhydride in an one pot three component reaction. In this reaction substituents on carbonyl compounds have played a key role in yield of the product formation. Carbonyl compounds with either electron withdrawing or electron releasing substituents have formed better percentage of products than un-substituted and sterically hindered compounds.
Item Type: | Article |
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Subjects: | Open Library Press > Chemical Science |
Depositing User: | Unnamed user with email support@openlibrarypress.com |
Date Deposited: | 16 Jun 2023 06:06 |
Last Modified: | 21 Sep 2024 03:56 |
URI: | http://info.euro-archives.com/id/eprint/1548 |