Kim, Janice J. and Khan, Waliul I. (2014) 5-HT7 receptor signaling: improved therapeutic strategy in gut disorders. Frontiers in Behavioral Neuroscience, 8. ISSN 1662-5153
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Abstract
Serotonin (5-hydroxytryptamine; 5-HT) is most commonly known for its role as a neurotransmitter in the central nervous system (CNS). However, the majority of the body’s 5-HT is produced in the gut by enterochromaffin (EC) cells. Alterations in 5-HT signaling have been associated with various gut disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and enteric infections. Recently, our studies have identified a key role for 5-HT in the pathogenesis of experimental colitis. 5-HT7 receptors are expressed in the gut and very recently, we have shown evidence of 5-HT7 receptor expression on intestinal immune cells and demonstrated a key role for 5-HT7 receptors in generation of experimental colitis. This review summarizes the key findings of these studies and provides a comprehensive overview of our current knowledge of the 5-HT7 receptor in terms of its pathophysiological relevance and therapeutic potential in intestinal inflammatory conditions, such as IBD.
Item Type: | Article |
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Subjects: | Open Library Press > Biological Science |
Depositing User: | Unnamed user with email support@openlibrarypress.com |
Date Deposited: | 08 Mar 2023 10:36 |
Last Modified: | 23 Sep 2024 04:07 |
URI: | http://info.euro-archives.com/id/eprint/717 |